Central nervous system tumors represent the most common solid tumors of childhood.
The heterogeneous group of gliomas comprises the majority of pediatric tumors while
embryonal neoplasms represent the second most frequent group of tumors. Histopathological
diagnosis according to World Health Organization is of great importance for defining
prognosis and choosing the appropriate treatment. Recently, attempts have been made
to correlate specific genomic alterations to clinical outcome. Adding molecular information
to classic histology seems to improve diagnostic accuracy and risk stratification
of patients.
Keywords
gliomas - medulloblastoma - pediatric - histology - molecular biology
